VHH Science

 VHH Antibody Discovery
& Development Pathway


 Technology background

VHH single domain from camelid species: alpacas, camels etc

Single monomeric variable antibody domain of 15 kDa

Small size permits access to novel epitopes inaccessible to monoclonal IgG antibodies

Excellent biophysical properties: high solubility, temperature stability

Clinically validated technology in human medicine with low potential for immunogenicity

Flexible and modular formatting: tunable half-life in serum, bi-/multi-specific binders

High potential for low manufacturing cost of goods: high antibody expression titres and microbial expression systems (Pichia, E.coli)