VHH Science
VHH Antibody Discovery
& Development Pathway


Technology background
VHH single domain from camelid species: alpacas, camels etc
Single monomeric variable antibody domain of 15 kDa
Small size permits access to novel epitopes inaccessible to monoclonal IgG antibodies
Excellent biophysical properties: high solubility, temperature stability
Clinically validated technology in human medicine with low potential for immunogenicity
Flexible and modular formatting: tunable half-life in serum, bi-/multi-specific binders
High potential for low manufacturing cost of goods: high antibody expression titres and microbial expression systems (Pichia, E.coli)
